Week 1 · NFL · Neutral site
San Francisco 49ers vs Los Angeles Rams prediction
The TailgateNinjas model gives Los Angeles Rams a 60% chance to beat San Francisco 49ers in this NFL matchup. Updated August 4, 2026.
#6 NFC West
San Francisco 49ers
70% to make the playoffs
#2 NFC West
Los Angeles Rams
82% to make the playoffs
The model's read
A coin flip. The model nudges Los Angeles Rams by a field goal — 60% to win.
San Francisco 49ers
40%
to win
Los Angeles Rams
60%
to win
Who wins?
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Tale of the tape
2025 efficiency · ranksSan Francisco 49ersLos Angeles RamsNational ranks from last season (1 = best). The 2026 outlook builds on this.
Series history
55 meetings since 1999San Francisco 49ers leads 30–24–1
Last met 2025 · San Francisco 49ers 26–42 Los Angeles Rams— Los Angeles Rams won
Both sidelines
via Google NewsWhat San Francisco 49ers is hearing
What Los Angeles Rams is hearing
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