Week 3 · NFL

Arizona Cardinals vs San Francisco 49ers prediction

The TailgateNinjas model gives San Francisco 49ers a 80% chance to beat Arizona Cardinals in this NFL matchup. Updated August 4, 2026.

#31 NFC West

Arizona Cardinals

0% to make the playoffs

@

#6 NFC West

San Francisco 49ers

70% to make the playoffs

The model's read

SpreadSan Francisco 49ers −11.5Vegas
Projected scoreArizona Cardinals 16 — San Francisco 49ers 28

San Francisco 49ers should handle it: 11.5-point edge, 80% to win.

Chaos meter39 · LEAN
39/ 100
CalmMayhem

Arizona Cardinals

20%

to win

San Francisco 49ers

80%

to win

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Tale of the tape

2025 efficiency · ranks
Arizona Cardinals
vs
San Francisco 49ers
#23Offense · EPA/play#6
#27Defense · EPA/play#24
#22Success rate#4

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

50 meetings since 1999

San Francisco 49ers leads 28–22

Last met 2025 · Arizona Cardinals 22–41 San Francisco 49ers— San Francisco 49ers won

Both sidelines

via Google News

What Arizona Cardinals is hearing

What San Francisco 49ers is hearing

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