Week 4 · NFL

Denver Broncos vs San Francisco 49ers prediction

The TailgateNinjas model gives San Francisco 49ers a 57% chance to beat Denver Broncos in this NFL matchup. Updated August 4, 2026.

#14 AFC West

Denver Broncos

63% to make the playoffs

#6 NFC West

San Francisco 49ers

70% to make the playoffs

The model's read

SpreadSan Francisco 49ers −2.5Vegas

Projected scoreDenver Broncos 21 — San Francisco 49ers 23

A coin flip. The model nudges San Francisco 49ers by a field goal — 57% to win.

Chaos meter85 · TOSS-UP

85/ 100

CalmMayhem

Denver Broncos

43%

to win

San Francisco 49ers

57%

to win

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2025 efficiency · ranks

Denver Broncos

San Francisco 49ers

#10Offense · EPA/play#6

#6Defense · EPA/play#24

#16Success rate#4

National ranks from last season (1 = best). The 2026 outlook builds on this.

7 meetings since 1999

Denver Broncos leads 4–3

Last met 2022 · Denver Broncos 11–10 San Francisco 49ers— Denver Broncos won

via Google News

What Denver Broncos is hearing

What San Francisco 49ers is hearing

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