Week 13 · NFL

San Francisco 49ers vs New York Giants prediction

The TailgateNinjas model gives San Francisco 49ers a 63% chance to beat New York Giants in this NFL matchup. Updated August 4, 2026.

#6 NFC West

San Francisco 49ers

70% to make the playoffs

@

#22 NFC East

New York Giants

12% to make the playoffs

The model's read

SpreadSan Francisco 49ers −4.5Model
Projected scoreSan Francisco 49ers 24 — New York Giants 20

San Francisco 49ers is the pick by 4.5, but it's live — 63% on the model.

Chaos meter74 · LIVE
74/ 100
CalmMayhem

San Francisco 49ers

63%

to win

New York Giants

37%

to win

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Tale of the tape

2025 efficiency · ranks
San Francisco 49ers
vs
New York Giants
#6Offense · EPA/play#17
#24Defense · EPA/play#25
#4Success rate#25

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

15 meetings since 1999

San Francisco 49ers leads 8–7

Last met 2025 · New York Giants 24–34 San Francisco 49ers— San Francisco 49ers won

Both sidelines

via Google News

What San Francisco 49ers is hearing

What New York Giants is hearing

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