Week 18 · NFL

San Francisco 49ers vs Arizona Cardinals prediction

The TailgateNinjas model gives San Francisco 49ers a 76% chance to beat Arizona Cardinals in this NFL matchup. Updated August 4, 2026.

#6 NFC West

San Francisco 49ers

70% to make the playoffs

@

#31 NFC West

Arizona Cardinals

0% to make the playoffs

The model's read

SpreadSan Francisco 49ers −9.5Model
Projected scoreSan Francisco 49ers 27 — Arizona Cardinals 17

San Francisco 49ers should handle it: 9.5-point edge, 76% to win.

Chaos meter48 · LEAN
48/ 100
CalmMayhem

San Francisco 49ers

76%

to win

Arizona Cardinals

24%

to win

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Tale of the tape

2025 efficiency · ranks
San Francisco 49ers
vs
Arizona Cardinals
#6Offense · EPA/play#23
#24Defense · EPA/play#27
#4Success rate#22

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

50 meetings since 1999

San Francisco 49ers leads 28–22

Last met 2025 · Arizona Cardinals 22–41 San Francisco 49ers— San Francisco 49ers won

Both sidelines

via Google News

What San Francisco 49ers is hearing

What Arizona Cardinals is hearing

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