Week 1 · NFL

Arizona Cardinals vs Los Angeles Chargers prediction

The TailgateNinjas model gives Los Angeles Chargers a 78% chance to beat Arizona Cardinals in this NFL matchup. Updated August 4, 2026.

#31 NFC West

Arizona Cardinals

0% to make the playoffs

@

#11 AFC West

Los Angeles Chargers

67% to make the playoffs

The model's read

SpreadLos Angeles Chargers −10.5Vegas
Projected scoreArizona Cardinals 17 — Los Angeles Chargers 27

Los Angeles Chargers should handle it: 10.5-point edge, 78% to win.

Chaos meter44 · LEAN
44/ 100
CalmMayhem

Arizona Cardinals

22%

to win

Los Angeles Chargers

78%

to win

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Tale of the tape

2025 efficiency · ranks
Arizona Cardinals
vs
Los Angeles Chargers
#23Offense · EPA/play#25
#27Defense · EPA/play#7
#22Success rate#19

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

8 meetings since 1999

Los Angeles Chargers leads 5–3

Last met 2024 · Arizona Cardinals 17–15 Los Angeles Chargers— Arizona Cardinals won

Both sidelines

via Google News

What Arizona Cardinals is hearing

What Los Angeles Chargers is hearing

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