Week 12 · College Football
Pittsburgh vs Louisville prediction
The TailgateNinjas model gives Louisville a 61% chance to beat Pittsburgh in this College Football matchup. Updated August 29, 2026.
#38 Atlantic Coast Conference
Pittsburgh
11% to make the 12
#39 Atlantic Coast Conference
Louisville
13% to make the 12
The model's read
Louisville is the pick by 4.5, but it's live — 61% on the model.
Pittsburgh
39%
to win
Louisville
61%
to win
Who wins?
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Pick this game against the spread
Tale of the tape
2025 efficiency · ranksPittsburghLouisvilleNational ranks from last season (1 = best). The 2026 outlook builds on this.
Series history
22 meetings all-timeAll square 11–11
Last met 2025 · Pittsburgh 27–34 Louisville— Louisville won
Both sidelines
via Google NewsWhat Pittsburgh is hearing
What Louisville is hearing
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