Week 16 · NFL

San Francisco 49ers vs Kansas City Chiefs prediction

The TailgateNinjas model gives Kansas City Chiefs a 54% chance to beat San Francisco 49ers in this NFL matchup. Updated August 4, 2026.

#6 NFC West

San Francisco 49ers

70% to make the playoffs

@

#8 AFC West

Kansas City Chiefs

80% to make the playoffs

The model's read

SpreadKansas City Chiefs −1.5Model
Projected scoreSan Francisco 49ers 21 — Kansas City Chiefs 23

A coin flip. The model nudges Kansas City Chiefs by a field goal — 54% to win.

Chaos meter91 · TOSS-UP
91/ 100
CalmMayhem

San Francisco 49ers

46%

to win

Kansas City Chiefs

54%

to win

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Tale of the tape

2025 efficiency · ranks
San Francisco 49ers
vs
Kansas City Chiefs
#6Offense · EPA/play#11
#24Defense · EPA/play#12
#4Success rate#14

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

10 meetings since 1999

Kansas City Chiefs leads 7–3

Last met 2024 · San Francisco 49ers 18–28 Kansas City Chiefs— Kansas City Chiefs won

Both sidelines

via Google News

What San Francisco 49ers is hearing

What Kansas City Chiefs is hearing

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