Week 1 · College Football · Neutral site

Louisville vs Ole Miss prediction

The TailgateNinjas model gives Ole Miss a 69% chance to beat Louisville in this College Football matchup. Updated August 29, 2026.

#39 Atlantic Coast Conference

Louisville

13% to make the 12

@

#15 Southeastern Conference

Ole Miss

21% to make the 12

The model's read

SpreadOle Miss −7.5Vegas
Projected scoreLouisville 22 — Ole Miss 30

Ole Miss is the pick by 7.5, but it's live — 69% on the model.

Chaos meter63 · LIVE
63/ 100
CalmMayhem

Louisville

31%

to win

Ole Miss

69%

to win

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Tale of the tape

2025 efficiency · ranks
Louisville
vs
Ole Miss
#82Offense · EPA/play#11
#21Defense · EPA/play#49
#97Explosiveness#45
#37Success rate#12
46%Returning production18%

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

1 meeting all-time

Ole Miss leads 1–0

Last met 2021 · Ole Miss 43–24 Louisville (neutral)— Ole Miss won

Both sidelines

via Google News

What Louisville is hearing

What Ole Miss is hearing

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