Week 2 · NFL

Detroit Lions vs Buffalo Bills prediction

The TailgateNinjas model gives Buffalo Bills a 60% chance to beat Detroit Lions in this NFL matchup. Updated August 4, 2026.

#9 NFC North

Detroit Lions

69% to make the playoffs

@

#5 AFC East

Buffalo Bills

85% to make the playoffs

The model's read

SpreadBuffalo Bills −3.5Vegas
Projected scoreDetroit Lions 20 — Buffalo Bills 24

A coin flip. The model nudges Buffalo Bills by a field goal — 60% to win.

Chaos meter80 · TOSS-UP
80/ 100
CalmMayhem

Detroit Lions

40%

to win

Buffalo Bills

60%

to win

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Tale of the tape

2025 efficiency · ranks
Detroit Lions
vs
Buffalo Bills
#7Offense · EPA/play#3
#14Defense · EPA/play#13
#12Success rate#2

National ranks from last season (1 = best). The 2026 outlook builds on this.

Series history

7 meetings since 1999

Buffalo Bills leads 6–1

Last met 2024 · Detroit Lions 42–48 Buffalo Bills— Buffalo Bills won

Both sidelines

via Google News

What Detroit Lions is hearing

What Buffalo Bills is hearing

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